Legg-Calve-Perthes disease, protein C deficiency, and beta-thalassemia major: Report of two cases

Legg-Calve-Perthes disease is an idiopathic osteonecrosis or avascular necr osis of the capital femoral epiphysis and the associated complications ther eof occurring in an immature growing child. The association between osteone crosis of the femoral head and thrombophilia was postulated by Glueck in 19 94. We describe Legg-Calve-Perthes disease associated with protein C defici ency and beta-thalassemia major in two children among a cohort of 79 beta-t halassemia patients treated in our clinic. The association of thrombophilia , aseptic necrosis of the femoral head, and beta-thalassemia has not been p reviously described in the literature.