The role of endothelium in antithrombotic effect of the renin-angiotensin system blockade

Authors
Buczko, W Matys, T Kucharewicz, I Chabielska, E
Citation
W. Buczko et al., The role of endothelium in antithrombotic effect of the renin-angiotensin system blockade, J PHYSL PH, 50(4), 1999, pp. 499-507
Citations number
50
Categorie Soggetti
Physiology
Journal title
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
ISSN journal
08675910 → ACNP
Volume
50
Issue
4
Year of publication
1999
Pages
499 - 507
Database
ISI
SICI code
0867-5910(199912)50:4<499:TROEIA>2.0.ZU;2-3
Abstract
Drugs blocking the renin-angiotensin system, angiotensin converting enzyme inhibitors and AT(1) receptor antagonists, among many pharmacological effec ts may exert an antithrombotic action. The mechanisms, which mediate their antithrombotic activity are associated with enhanced nitric oxide and prost acyclin release or with attenuation of angiotensin IT action (;Fig. I, 2). Nevertheless, endothelium plays an important role in this process linking t he renin-angiotensin and fibrinolysis/coagulation systems.