IL-12 reverses the suppressive effect of the CD40 ligand blockade on experimental autoimmune encephalomyelitis (EAE)

Citation
Cs. Constantinescu et al., IL-12 reverses the suppressive effect of the CD40 ligand blockade on experimental autoimmune encephalomyelitis (EAE), J NEUR SCI, 171(1), 1999, pp. 60-64
Citations number
42
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF THE NEUROLOGICAL SCIENCES
ISSN journal
0022510X → ACNP
Volume
171
Issue
1
Year of publication
1999
Pages
60 - 64
Database
ISI
SICI code
0022-510X(199912)171:1<60:IRTSEO>2.0.ZU;2-8
Abstract
Blockade of the CD40 ligand (CD40L)-CD40 interaction suppresses experimenta l autoimmune encephalomyelitis (EAE). Since this interaction induces IL-12, an essential cytokine for EAE induction, we hypothesized that CD40L blocka de may suppress EAE through IL-12, inhibition. Here we show that exogenous IL-12, abolishes the ability of anti-CD40L monoclonal antibodies to prevent EAE. Anti-IL-12 antibodies prevent this reversal and protect from EAE. The se results show that IL-12 is sufficient to overcome CD40L blockade and sug gest that, of the multiple consequences of the CD40L-CD40 interaction IL-12 induction is an essential one far induction of EAE. (C) 1999 Elsevier Scie nce B.V. All rights reserved.