Cerebral venous sinus thrombosis associated with hepatic cirrhosis

Cerebral venous sinus thrombosis is not a recognized complication of end-st age liver disease. A case of sagittal sinus thrombosis in a 44-year-old mal e with end-stage hepatic cirrhosis is described. Recurrent seizures were th e only manifestation. Work-up revealed severe deficiency of protein C, prot ein S, and antithrombin III. He was treated with low molecular weight hepar in and underwent an orthotopic liver transplant after three months. Follow- up helical CT venogram showed resolution of the sinus thrombosis. (C) 1999 Elsevier Science B.V. All rights reserved.