Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice

Control of ganglionic herpes simplex virus (HSV) infection depends on CD8() cells but not on the death of infected neurons. Primarily, perforin and g ranzyme B mediate CD8(+) cell cytotoxicity, whereas the in vivo functions o f granzyme A, a third granule protein, are unknown, Here, it is shown that granzyme A restricts the interneuronal spread of HSV and significantly infl uences ganglionic virus load.