Increased CD38 expression is associated with favorable prognosis in adult acute leukemia

Authors
Keyhani, A Huh, YO Jendiroba, D Pagliaro, L Cortez, J Pierce, S Pearlman, M Estey, E Kantarjian, H Freireich, EJ
Citation
A. Keyhani et al., Increased CD38 expression is associated with favorable prognosis in adult acute leukemia, LEUK RES, 24(2), 2000, pp. 153-159
Citations number
21
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA RESEARCH
ISSN journal
01452126 → ACNP
Volume
24
Issue
2
Year of publication
2000
Pages
153 - 159
Database
ISI
SICI code
0145-2126(200002)24:2<153:ICEIAW>2.0.ZU;2-G
Abstract
CD38 is expressed in acute lymphoblastic leukemia (ALL) and acute myelogeno us leukemia (AML) blasts and its prognostic significance is unknown. We inv estigated CD38 expression in 304 AML and 138 ALL patients. CD38 was lower i n AML-M3 compared to other FAB subtypes (5% vs. 41%; P < 0.001), but was si milar among ALL subtypes (56.6%; P = 0.69). Ph + ALL and AML with t(15;17) patients showed lower CD38 expression than the other cytogenetic groups. Ov erall survival favored AML and ALL patients with higher CD38 levels. Multiv ariate analysis revealed CD38 expression to be an independent outcome predi ctor in AML, but not in ALL. (C) 2000 Elsevier Science Ltd. All rights rese rved.