S. Hashimoto et al., Grepafloxacin inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in human airway epithelial cells, LIFE SCI, 66(5), 2000, pp. PL77-PL82
We examined the effect of grepafloxacin (GPFX), a new fluoroquinolone antim
icrobial agent, on interleukin-8 (IL-8) expression in tumor necrosis factor
-alpha (TNF-alpha)-stimulated human airway epithelial cells (AEC). GPFX inh
ibited IL-8 protein production as well as mRNA expression in a concentratio
n-dependent manner (2.5 - 25 mu g/ml), but the inhibition of IL-8 expressio
n by corresponding concentrations of GPFX to serum and airway lining fluids
was not complete. We discuss the modulatory effect of GPFX on IL-8 product
ion in the context of its efficacy on controlling chronic airway inflammato
ry diseases. (C) 1999 Elsevier Science Inc.