A POSSIBLE ROLE OF COLLAGEN FIBRILS IN THE PROCESS OF CALCIFICATION OBSERVED IN THE CAPSULE OF THE PINEAL-GLAND IN AGING RATS

Authors
HUMBERT W CUISINIER F VOEGEL JC PEVET P
Citation
W. Humbert et al., A POSSIBLE ROLE OF COLLAGEN FIBRILS IN THE PROCESS OF CALCIFICATION OBSERVED IN THE CAPSULE OF THE PINEAL-GLAND IN AGING RATS, Cell and tissue research, 288(3), 1997, pp. 435-439
Citations number
24
Categorie Soggetti
Cell Biology
Journal title
Cell and tissue research → ACNP
ISSN journal
0302766X
Volume
288
Issue
3
Year of publication
1997
Pages
435 - 439
Database
ISI
SICI code
0302-766X(1997)288:3<435:APROCF>2.0.ZU;2-Y
Abstract
The relationship between collagen fibrils and calcified concretions ex clusively appearing in the pineal gland of adult/aging rats has been i nvestigated. Deposits of lanthanum, which replace calcium ions are dis tributed along collagen fibrils with a repeating period of about 70 nm , Calcium has been detected histochemically between collagen bundles s urrounding extracellular concretions by means of the pyroantimonate me thod and by X-ray microanalysis. It is associated with phosphorus. The data presented here suggest that collagen fibrils are involved in the genesis and growth of extracellular concretions located in the connec tive tissue surrounding the pineal gland of aging rats.