Phosphorylation of the synthetic octapeptide pyroGlu-ASP-ASP-SER-ASP-GLU-GLU-ASN and binding to DNA in presence of divalent cations

Authors
Cardellini, E Ponti, D Gianfranceschi, GL
Citation
E. Cardellini et al., Phosphorylation of the synthetic octapeptide pyroGlu-ASP-ASP-SER-ASP-GLU-GLU-ASN and binding to DNA in presence of divalent cations, MOL BIOL RP, 26(4), 1999, pp. 255-259
Citations number
19
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY REPORTS
ISSN journal
03014851 → ACNP
Volume
26
Issue
4
Year of publication
1999
Pages
255 - 259
Database
ISI
SICI code
0301-4851(199912)26:4<255:POTSOP>2.0.ZU;2-6
Abstract
Small acidic peptides involved in gene expression have been isolated from p rokaryotic and eukaryotic cells. Synthetic peptides, designed on the basis of native peptides characteristics, show a biological activity similar to t hat of native peptides in in vitro reconstituted systems. These synthetic p eptides are able to bind to DNA in presence of divalent cations (Cu2+, Fe2, Mg2+) and salt/ethanol.