Sj. Kiebel et al., Robust smoothness estimation in statistical parametric maps using standardized residuals from the general linear model, NEUROIMAGE, 10(6), 1999, pp. 756-766
The assessment of significant activations in functional imaging using voxel
-based methods often relies on results derived from the theory of Gaussian
random fields. These results solve the multiple comparison problem and assu
me that the spatial correlation or smoothness of the data is known or can b
e estimated. End results (i.e., P values associated with local maxima, clus
ters, or sets of clusters) critically depend on this assessment, which shou
ld be as exact and as reliable as possible. In some earlier implementations
of statistical parametric mapping (SPM) (SPM94, SPM95) the smoothness was
assessed on Gaussianized t-fields (Gt-f) that are not generally free of phy
siological signal. This technique has two limitations. First, the estimatio
n is not stable (the variance of the estimator being far from negligible) a
nd, second, physiological signal in the Gt-f will bias the estimation. In t
his paper, we describe an estimation method that overcomes these drawbacks.
The new approach involves estimating the smoothness of standardized residu
al fields which approximates the smoothness of the component fields of the
associated t-field. Knowing the smoothness of these component fields is imp
ortant because it allows one to compute corrected P values for statistical
fields other than the t-field or the Gt-f (e.g., the F-map) and eschews bia
s due to deviation from the null hypothesis. We validate the method on simu
lated data and demonstrate it using data from a functional MRI study. (C) 1
999 Academic Press.