New triterpenoids with antibacterial activity from Zizyphus joazeiro

Authors
Schuhly, W Heilmann, J Calis, I Sticher, O
Citation
W. Schuhly et al., New triterpenoids with antibacterial activity from Zizyphus joazeiro, PLANTA MED, 65(8), 1999, pp. 740-743
Citations number
11
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
65
Issue
8
Year of publication
1999
Pages
740 - 743
Database
ISI
SICI code
0032-0943(199912)65:8<740:NTWAAF>2.0.ZU;2-H
Abstract
The stem bark of the Brazilian medicinal plant Zizyphus joazeiro C. Mart. w as phytochemically investigated. Three known compounds (betulinic, ursolic and alphitolic acid) and three new derivatives of betulinic acid, 7 beta-(4 -hydroxybenzoyloxy)-betulinic acid, 7 beta(4-hydroxy-3'-methoxybenzoyloxy)b etulinic acid and 27-(4-hydroxy-3'-methoxybenzoyloxy)-betulinic acid which showed a considerable activity against Gram-positive bacteria were isolated from the dichloromethane extract. The structures were established on the b asis of NMR spectroscopy and mass spectrometry.