Antimalarials from Stephania venosa, Prismatomeris sessiliflora, Diospyrosmontana and Murraya siamensis

Authors
Likhitwitayawuid, K Dej-adisai, S Jongbunprasert, V Krungkrai, J
Citation
K. Likhitwitayawuid et al., Antimalarials from Stephania venosa, Prismatomeris sessiliflora, Diospyrosmontana and Murraya siamensis, PLANTA MED, 65(8), 1999, pp. 754-756
Citations number
20
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
65
Issue
8
Year of publication
1999
Pages
754 - 756
Database
ISI
SICI code
0032-0943(199912)65:8<754:AFSVPS>2.0.ZU;2-Q
Abstract
Fourteen compounds isolated from Stephania venosa, Prismatomeris sessiliflo ro, Diospyros montana and Murraya siamensis were tested for their antimalar ial potential. The 6a,7-dehydroaporphine alkaloids dehydrostephanine and de hydrocrebanine showed potent activity with IC50 values of 40 and 70 ng/ml, respectively. The C-13-NMR data of rubiadin, rubiadin-1-methyl ether, diosp yrin and 5-hydroxy-4-methoxy-2-naphthaldehyde were extensively studied.