Human articular cartilage: Influence of aging and early symptomatic degeneration on the spatial variation of T2 - Preliminary findings at 3 T

PURPOSE: To determine if age and early symptomatic degeneration alter the s patial dependency of cartilage T2. MATERIALS AND METHODS: In 25 asymptomatic volunteers and six volunteers wit h symptoms of patellar chondromalacia, quantitative T2 maps of patellar car tilage were obtained with a multiecho, spin-echo magnetic resonance imaging sequence at 3.0 T. Spatial variation in T2 was evaluated as a function df participant age and symptoms. RESULTS: All asymptomatic volunteers demonstrated a continuous increase in T2 from the radial zone to the articular surface. In the population aged 46 -60 years compared with younger volunteers, there was a statistically signi ficant (P<.05) increase in T2 of the transitional zone. in symptomatic volu nteers, the increase in T2 was larger in magnitude and focal in distributio n. In five of the six symptomatic volunteers, the increase in T2 was greate r than the 95% prediction interval determined from data in the correspondin g age-matched asymptomatic population. CONCLUSION: Aging is associated with an asymptomatic; increase in T2 of the transitional zone of articular Cartilage. Preliminary results: indicate th is diffuse increase in T2 in senescent cartilage is different :in;appearanc e than the focally increased T2 observed in damaged articular cartilage.