Synthesis of copolymers of N-(2-hydroxypropyl)methacrylamide with acrylic acid and gentamicin salts of these copolymers

Authors
Solovskii, MV Denisov, VM Ryadinskaya, NY Petukhova, NA Okulova, NV
Citation
Mv. Solovskii et al., Synthesis of copolymers of N-(2-hydroxypropyl)methacrylamide with acrylic acid and gentamicin salts of these copolymers, RUS J AP CH, 72(8), 1999, pp. 1443-1449
Citations number
12
Categorie Soggetti
Chemistry
Journal title
RUSSIAN JOURNAL OF APPLIED CHEMISTRY
ISSN journal
10704272 → ACNP
Volume
72
Issue
8
Year of publication
1999
Pages
1443 - 1449
Database
ISI
SICI code
1070-4272(199908)72:8<1443:SOCONW>2.0.ZU;2-5
Abstract
Water-soluble copolymers of N-(2-hydroxypropyl)methacrylamide with acrylic acid were prepared by radical copolymerization in ethanol or isopropanol at 65 degrees C in the presence of azobis(isobutyronitrile). The composition and molecular weight of the copolymers were determined, and ways to control these parameters were revealed. Reaction of N-(2-hydroxypropyl)methacrylam ide-acrylic acid copolymers with an antibiotic gentamicin in aqueous soluti ons gave polymeric salts containing various amounts of this antibiotic. The ionic binding of gentamicin to the copolymers was confirmed by equilibrium dialysis.