Localized bullous pemphigoid in a patient with B-cell lymphoma

Bullous pemphigoid (BP) is an immunobullous disease characterized by circul ating IgG antibodies directed towards cutaneous basement zone antigens, We report the case of a patient who had BP localized to a stoma site. At initi al examination, a nodule was noted on the temple, which proved to be a larg e cell lymphoma, B-cell phenotype, On Western immunoblot, the patient's ser um showed circulating IgG antibodies reactive with the 230 kDa BP antigen a nd the 97 kDa linear IgA bullous dermatosis antigen. The co-incident onset of the two diseases suggest that this may represent a case of paraneoplasti c BP.