Wet and dry interfaces: the role of solvent in protein-protein and protein-DNA recognition

Authors
Janin, J
Citation
J. Janin, Wet and dry interfaces: the role of solvent in protein-protein and protein-DNA recognition, STRUCT F D, 7(12), 1999, pp. R277-R279
Citations number
21
Categorie Soggetti
Biochemistry & Biophysics
Journal title
STRUCTURE WITH FOLDING & DESIGN
ISSN journal
09692126 → ACNP
Volume
7
Issue
12
Year of publication
1999
Pages
R277 - R279
Database
ISI
SICI code
0969-2126(199912)7:12<R277:WADITR>2.0.ZU;2-V
Abstract
Water molecules are found in abundance in protein-protein and protein-DNA i nterfaces. Although interface solvent molecules exchange quickly with the b ulk solvent, structural and biochemical data suggest that water-mediated in teractions are as important as direct hydrogen bonds in the stability and s pecificity of recognition.