Unusual ring closure reaction of amides with pyrimidines: Novel stereoselective synthesis of hexahydroimidazo[1,2-c]pyrimidines

Authors
Acero-Alarcon, A Armero-Alarte, T Jorda-Gregori, JM Rojas-Argudo, C Zaballos-Garcia, E Server-Carrio, J Ahjyaje, FZ Sepulveda-Arques, J
Citation
A. Acero-alarcon et al., Unusual ring closure reaction of amides with pyrimidines: Novel stereoselective synthesis of hexahydroimidazo[1,2-c]pyrimidines, SYNTHESIS-S, (12), 1999, pp. 2124-2130
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
12
Year of publication
1999
Pages
2124 - 2130
Database
ISI
SICI code
0039-7881(199912):12<2124:URCROA>2.0.ZU;2-X
Abstract
Hexahydromidazo[1,2-c]pyrimidines 6 were prepared by the reaction of tosylp yrimidines 2 with bromoacetamides 3 in one step. The stereoselectivity of t he reaction has been confirmed by X-ray analysis. Imidazo[1,2-a]pyrimidines 5 were obtained on heating hexahydroimidazo[1,2-c]pyrimidines 6 with trifl uoroacetic anhydride.