The course of Lyme disease in different age groups

Lyme disease is a multisystem infection affecting all age groups. In this s tudy an attempt was made to determine whether the patient's age influences the course of the disease. One hundred and fifty patients with diagnosed Ly me disease were included in the study. Two serological methods were used to detect antibodies to Borrelia burgdorferi and to confirm the diagnosis: an indirect immunofluorescence assay (the Russian strain lp-21) and Western b lot. The course of Lyme disease did not differ from that seen in Europe and North America. However, a few clinical differences between groups were obs erved. In the first age group (0-15 years) the most common manifestation wa s flu-like symptoms with fever. Neither radiculoneuritis nor polyneuropathy was observed in this age group. Late manifestations were rare and the outc ome of the disease was benign. The course of the disease in the second grou p (16-40 years) was most similar to that in childhood and the also outcome was similar. Carditis and erythema multiple were significantly more common in the second group (16-40 years) than in the other age groups. No differen ces were found between the third (41-60 years) and fourth (> than 60 years) group in the frequency of flu-like symptoms, erythema multiple and aseptic meningitis. However, the most important clinical sign in this group was in volvement of the nervous system whereas in the third group this was joint d amage. This feature deserves attention because, as a rule, the presence of an articular syndrome determines the prognosis of LD.