SIMULATION OF MEASUREMENTS OF UPTAKE OF I-123 IODIDE IN THE THYROID OF FETAL CHIMPANZEES

Citation
Jl. Noteboom et al., SIMULATION OF MEASUREMENTS OF UPTAKE OF I-123 IODIDE IN THE THYROID OF FETAL CHIMPANZEES, Radiation research, 147(6), 1997, pp. 686-690
Citations number
7
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
ISSN journal
00337587
Volume
147
Issue
6
Year of publication
1997
Pages
686 - 690
Database
ISI
SICI code
0033-7587(1997)147:6<686:SOMOUO>2.0.ZU;2-7
Abstract
The quantitative assessment of the uptake of I-123-iodide (I-123(-)) i n the fetal thyroid in vivo was simulated in phantom measurements. Fir st, the relationship between the depth of the fetal thyroid phantom an d the two-peak ratio, the ratio of the counts in the gamma-ray and the X-ray energy windows of the registered spectrum, was determined. Subs equently, the attenuation of the gamma-ray signal in relationship to t he depth of the fetal thyroid phantom was determined, Finally, the rel ationship between the two-peak ratio and the attenuation of the gamma- ray signal was deduced. For a reliable correlation, the signal recorde d from the radioactivity surrounding the fetal thyroid phantom has to be subtracted from that obtained with the fetal thyroid phantom presen t. A correction curve was generated to be applied to the in vivo measu rements. It is concluded that with this method determination of uptake of I-123(-) in the fetal thyroid is feasible. (C) 1997 by Radiation R esearch Society.