4 NOVEL CYCLOARTANE GLYCOSIDES FROM ASTRAGALUS-OLEIFOLIUS

Four novel cycloartane-type triterpene glycosides, macrophyllosaponins A-D (1-4) were isolated from the roots of Astragalus oleifolius. By m eans of chemical (acetylation, alkaline hydrolysis) and spectroscopic methods (IR, 1D- and 2D-NMR, FABMS), their structures were established as 3-O-alpha-L-rhamnopyranosyl-24-O-(4 ''-O-acetyl)-beta-D-xylopyrano syl-1 alpha,3 beta,7 beta,24(S),25-pentahydroxycycloartane (1), lpha-L -rhamnopyranosyl-24-O-beta-D-xylopyranosyl-1 alpha,3 beta,7 beta,24(S) ,25-pentahydroxycycloartane (2), lpha-L-rhamnopyranosyl-25-O-beta-D-gl ucoyranosyl-1 alpha,3 beta,7 beta,24(S),25-pentahydroxycycloartane (3) , and -(2-O-beta-D-xylopyranosyl)-beta-D-xylopyranosyl-1 alpha,3 beta, 7 beta,24(S),25-pentahydroxycycloartane (4).