Inhibition of tumor growth by interleukin 10 gene transfer in B16(F10) melanoma cells

Authors
Walos, S Szary, J Szala, S
Citation
S. Walos et al., Inhibition of tumor growth by interleukin 10 gene transfer in B16(F10) melanoma cells, ACT BIOCH P, 46(4), 1999, pp. 967-970
Citations number
22
Categorie Soggetti
Biochemistry & Biophysics
Journal title
ACTA BIOCHIMICA POLONICA
ISSN journal
0001527X → ACNP
Volume
46
Issue
4
Year of publication
1999
Pages
967 - 970
Database
ISI
SICI code
0001-527X(1999)46:4<967:IOTGBI>2.0.ZU;2-9
Abstract
Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antit umor activity. The effect of IL-10 on tumor growth was tested in murine mel anoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10 tumor growth was decreased depending on th e amount of secreted IL-10.