While overall alcohol consumption and alcohol-related automobile deaths hav
e declined, rates of alcohol dependence, liver cirrhosis, and alcohol-relat
ed problems remain high among adults, and binge drinking continues as a maj
or health risk for high school and college students. Some individual-level
downstream interventions have been evaluated with sufficient rigor to recom
mend widespread dissemination, and widened availability of new pharmacother
apies could further increase effectiveness. Midstream population-based prog
rams, such as screening and brief interventions in hospitals and managed ca
re organizations, may have greater public health impact than tertiary treat
ment because of early identification and low cost. Upstream programs and po
licies that place limits on alcohol availability (e.g., higher legal purcha
sing age) have the greatest potential to reduce morbidity and mortality at
the least cost to society.