Advanced Hodgkin's disease in a pregnant HIV seropositive woman: Favorablemother and baby outcome following combined anticancer and antiretroviral therapy

We describe a 33 y/o HIV+ woman who developed advanced Hodgkin's disease (H D) during the 2nd trimester of her pregnancy. Combination chemotherapy and antiretroviral treatment along with opportunistic infection prophylaxis wer e administered. At term, while in partial remission, she delivered by a Cae sarian section a healthy baby, PCR-negative for HIV, A complete remission w as later achieved upon completion of the chemotherapy regimen. Since both t he incidence of HD and the proportion of young women among the HIV+ individ uals are increasing, it seems important to recognize that successful comple tion of pregnancy with no deterioration of accepted surrogate parameters of HIV disease progression is achievable in a carefully treated HIV+ pregnant woman with advanced HD. (C) 2000 Wiley-Liss, Inc.