PURPOSE: In recent years, several studies have shown the presence of vascul
ar, cardiac, and other organ pseudoexfoliative material in patients with oc
ular pseudoexfoliation. The purpose of this study was to determine whether
an association exists between ocular pseudoexfoliation and cardiovascular,
cerebrovascular, or all-cause mortality.
METHODS: This retrospective study included 472 residents of Olmsted County,
Minnesota, who were diagnosed with pseudoexfoliation syndrome or pseudoexf
oliative glaucoma at Mayo Clinic from 1976 through 1995. Of these 472 cases
, 151 subsequently died from 1976 through 1997. Cause of death for these pa
tients, as determined by the National Center for Health Statistics was comp
ared with the entire Rochester, Minnesota, population using Kaplan-Meier an
alysis.
RESULTS: Of the 472 patients with ocular pseudoexfoliation, 358 (76%) were
female and 114 (24%) were male. The mean age at diagnosis was 74 years, wit
h a SD of 10 years and a range from 39 to 106 years. Cardiovascular disease
resulted in 40 deaths, with a 15-year cumulative probability of cardiovasc
ular mortality of 22%, compared with an expected 20% (no significant differ
ence with P = .19). Cerebrovascular disease resulted in 26 deaths with a 15
-year cumulative probability of cerebrovascular mortality of 12%, compared
with an expected 10% (no significant difference with P = .38). Finally, the
15-year observed all-cause cumulative mortality was 53% versus an expected
rate of 59% (significant difference with P = .0002).
CONCLUSIONS: No association was found between ocular pseudoexfoliation and
cardiovascular or cerebrovascular mortality. All-cause mortality was signif
icantly less in patients with ocular pseudoexfoliation. (Am J Ophthalmol 20
00;129:83-86. (C) 2000 by Elsevier Science Inc. All rights reserved.)