Combined intraepithelial squamous neoplasia and atypical fibroxanthoma of the cornea and limbos

PURPOSE: To investigate a case of an unusual neoplasm of the cornea and lim bus. METHODS: A 59-year-old man presented with a highly vascularized, nodular ma ss involving the left cornea and limbus. An excisional biopsy and, subseque ntly, a superficial lamellar keratectomy and multiple conjunctival biopsies were performed. At the 6 month follow-up examination, repeat conjunctival biopsies were performed. RESULTS: Histopathologic examination of the corneal specimen showed a high- grade intraepithelial squamous neoplasia (in situ carcinoma) overlying an a typical fibroxanthoma. CONCLUSION: We report the clinical and histologic appearance of a corneal/l imbal neoplasm consisting of an intraepithelial squamous neoplasia and an a typical fibroxanthoma. (Am J Ophthalmol 2000;129:94-96. (C) 2000 by Elsevie r Science Inc. All rights reserved.)