Detection of HPV-20, HPV-23, and HPV-DL332 in a solitary eyelid syringoma

PURPOSE: To report evidence of many human papilloma virus types occurring i n a solitary syringoma clinically appearing as a papilloma. METHODS: A 57-year-old man presented with a 10-year history of an upper eye lid tumor. Histopathology, human papillomavirus-nested polymerase chain rea ction, human papillomavirus-DNA cloning into vector pCR2.1, sequencing, and computer assisted evaluation were performed. RESULTS: Histopathology demonstrated a solitary benign syringoma, HPV-20 an d HPV-23 were present in one clone each, and HPV-5-related HPV-DL332 was pr esent in 9 clones. CONCLUSION: Many human papillomavirus types may be detected in an ocular sy ringoma. (Am J Ophthalmol 2000;129:99-101. (C) 2000 by Elsevier Science Inc . All rights reserved.)