Multiple retinal arteriolar occlusions associated with coexisting primary antiphospholipid syndrome and factor V Leiden mutation

PURPOSE: To investigate a case of a young woman with both primary antiphosp holipid syndrome and factor V Leiden mutation who developed multiple retina l arteriolar occlusions. METHOD: Case report of a 25-year-old woman with history and laboratory test s confirming the diagnosis of both primary antiphospholipid syndrome and fa ctor V Leiden mutation who presented with blurred vision in both eyes. RESULTS: Multiple retinal arteriolar occlusions were observed in both of he r eyes. The patient was treated first with heparin and then with warfarin. CONCLUSIONS: Primary antiphospholipid syndrome and factor V Leiden mutation , as well as other forms of thrombophilia, should be considered in the diff erential diagnosis of unexplained retinal vascular occlusions. The coexiste nce of several thrombophilic disorders may carry a particularly high risk f or thrombotic manifestations. (Am J Ophthalmol 2000;129:106;108. (C) 2000 b y Elsevier Science Inc. All rights reserved.)