Disturbed gyrification of the prefrontal region in male schizophrenic patients: A morphometric postmortem study

Objective: The goal was to test the hypothesis that abnormalities of gyrifi cation are present in the prefrontal region of postmortem brains from schiz ophrenic patients. Method: The authors compared the prefrontal regions in b rains from 24 schizophrenic patients and 24 normal comparison subjects. The gyrification index, the ratio of inner and outer surface contours, was mea sured bilaterally in three different slices from each brain. Area measureme nts of gray and white matter were studied separately by planimetric analysi s in the same sections. In addition, a gray-to-white-matter ratio and an as ymmetry coefficient were computed. Results: The mean gyrification index on the right side was significantly higher in the male schizophrenic patients than in the comparison men. The gyrification index of the female patients w as not significantly different from that of the female comparison subjects. Analysis of area measurements revealed no significant differences. Conclus ions: As gyrification is an ontogenetic stable feature unaffected by atroph ic processes during aging, the gyrification abnormalities of the prefrontal region provide further evidence of the importance of a neurodevelopmental mechanism in the etiology of schizophrenia, at least in males.