Nd. Volkow et al., Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism, AM J PSYCHI, 157(1), 2000, pp. 75-80
Objective: Despite the well-documented loss of brain dopamine activity with
age, little is known about its functional consequences in healthy individu
als. This study investigates the relationship between measures of brain dop
amine D-2 receptors (molecules that transmit dopamine signals) and regional
brain glucose metabolism (a marker of brain function) in healthy individua
ls. Method: Thirty-seven healthy volunteers aged 24-86 years underwent posi
tron emission tomography scans after injection of [C-11]raclopride to asses
s dopamine D-2 receptors and [(18)]fluorodeoxyglucose to assess regional br
ain glucose metabolism. Two methods used to assess the correlations between
metabolism and dopamine D-2 receptors-pixel-by-pixel correlations and corr
elations in preselected regions of interest-were then compared. Results: D-
2 receptors as well as frontal and cingulate metabolism declined with age.
Regardless of the method used, significant correlations between metabolism
and D-2 receptors were found in the frontal cortex (Brodmann's areas 6, 7,
8, 9, 10, 11, 44, 45, 47), anterior cingulate gyrus (areas 24, 32), tempora
l cortex (area 21), and caudate. These correlations remained significant af
ter removing age effects (partial correlation). Conclusions: These results
provide the first link between age-related declines in brain dopamine activ
ity and frontal and cingulate metabolism, which supports the need to invest
igate the therapeutic utility of interventions that enhance dopamine functi
on in the elderly. The fact that correlations remained significant after re
moving age effects suggests that dopamine may influence frontal, cingulate,
and temporal metabolism regardless of age.