Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry

The basic principles and recent advances in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry are reviewed. A brief history of electrospray ionization is provided, along with a complete techn ical description of the technique, electrospray ionization variations, and advantages. Next, the fundamental principles of Fourier transform ion cyclo tron resonance mass spectrometry are covered, including ion cyclotron motio n, ion cyclotron resonance excitation, and image current detection. Instrum entation and methods used to couple these techniques are then described. To pics include ion source configuration, ion transport through a strong magne tic field gradient, and ion trapping methods. The article concludes with se lected applications that highlight the strengths of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.