Thalidomide for the treatment of acquired immunodeficiency syndrome-associated refractory oral ulcers

A case of severe, oral, not otherwise specified ulcers in a human immunodef iciency virus-infected patient is described. The lesions did not respond to acyclovir, prednisone, pentoxifylline, or foscarnet sodium therapy. Dramat ic clinical improvement and progressive ulcer healing were observed after s tarting oral thalidomide therapy. Clinicians should be aware of the usefuln ess of thalidomide for the treatment of acquired immunodeficiency syndrome- associated not otherwise specified ulcerations.