Identification and characterization of SorCS, a third member of a novel receptor family

Citation
G. Hermey et al., Identification and characterization of SorCS, a third member of a novel receptor family, BIOC BIOP R, 266(2), 1999, pp. 347-351
Citations number
30
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
266
Issue
2
Year of publication
1999
Pages
347 - 351
Database
ISI
SICI code
0006-291X(199912)266:2<347:IACOSA>2.0.ZU;2-9
Abstract
A novel receptor, SorCS, was isolated from murine brain. It shows homology to the mosaic receptor SorLA and the neurotensin receptor sortilin based on a common VPS10 domain which is the hallmark of this new receptor family. I n the N-terminus of SorCS two putative cleavage sites for the convertase fu rin mark the beginning of the VPS10 domain, followed by a module of imperfe ct leucine-rich repeats and a transmembrane domain. The short intracellular C-terminus contains consensus signals for rapid internalization. The ident ified putative binding motifs for SH2 and SH3 domains are unique in the fam ily of VPS10 domain receptors. SorCS is predominantly expressed in brain, b ut also in heart, liver, and kidney. SorCS transcripts detected by in situ hybridization in the murine central nervous system point to a neuronal expr ession. (C) 1999 Academic Press.