Synthesis and BZR affinity of pyrazolo[1,5-a]pyrimidine derivatives. Part 1: Study of the structural features for BZR recognition

Authors
Selleri, S Bruni, F Costagli, C Costanzo, A Guerrini, G Ciciani, G Costa, B Martini, C
Citation
S. Selleri et al., Synthesis and BZR affinity of pyrazolo[1,5-a]pyrimidine derivatives. Part 1: Study of the structural features for BZR recognition, BIO MED CH, 7(12), 1999, pp. 2705-2711
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
7
Issue
12
Year of publication
1999
Pages
2705 - 2711
Database
ISI
SICI code
0968-0896(199912)7:12<2705:SABAOP>2.0.ZU;2-T
Abstract
Examination of the pharmacophoric points of the pyrazolo[1,5-a]pyrimidine d erivatives, ligands for BZR, previously published led us to the design of a novel class of 3,6-diaryl-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-7-ones and to determine the groups involved in the BZR recognition. (C) 1999 Elsevier Science Ltd. All rights reserved.