C. Dupont et al., D-ring substituted rhazinilam analogues: Semisynthesis and evaluation of antitubulin activity, BIO MED CH, 7(12), 1999, pp. 2961-2969
Novel (-)- and (+)-rhazinilam derivatives substituted on the D-ring (compou
nds 3, 4, 5 and 6) have been prepared from (+)-vincadifformine 7 and (-)-ta
bersonine and evaluated against the disassembly of microtubules into tubuli
n. Along with this study, a reproducible 'one pot' semisynthesis of (-)-rha
zinilam 1 from (+)-1,2-didehydroaspidospermidine 2 was performed allowing t
he easy preparation of these new compounds. (C) 1999 Elsevier Science Ltd.
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