Synthesis of the repeating unit of the O-specific polysaccharide of Shigella sonnei and quantitation of its serologic activity

Authors
Toth, A Medgyes, A Bajza, I Liptak, A Batta, G Kontrohr, T Peterffy, K Pozsgay, V
Citation
A. Toth et al., Synthesis of the repeating unit of the O-specific polysaccharide of Shigella sonnei and quantitation of its serologic activity, BIOORG MED, 10(1), 2000, pp. 19-21
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
1
Year of publication
2000
Pages
19 - 21
Database
ISI
SICI code
0960-894X(20000103)10:1<19:SOTRUO>2.0.ZU;2-4
Abstract
The chemical synthesis of the zwitterionic disaccharide 2 is described that corresponds to the repeating unit of the O-specific polysaccharide (1) of the Gram-negative human pathogen Shigella sonnei. Passive hemolysis inhibit ion tests using a hyperimmune rabbit serum raised against S. sonnei showed that the serologic activity of the disaccharide 2 is nearly 2- to 3-fold hi gher than those of its component monosaccharides. NMR data of 2 are in supp ort of the proposed structure of the O-specific polysaccharide. (C) 1999 El sevier Science Ltd. All rights reserved.