Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2

Authors
Han, CK Ahn, SK Choi, NS Hong, RK Moon, SK Chun, HS Lee, SJ Kim, JW Hong, CI Kim, D Yoon, JH No, KT
Citation
Ck. Han et al., Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2, BIOORG MED, 10(1), 2000, pp. 39-43
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
1
Year of publication
2000
Pages
39 - 43
Database
ISI
SICI code
0960-894X(20000103)10:1<39:DASOHP>2.0.ZU;2-1
Abstract
New fumagillin analogues were designed through structure-based molecular mo deling with a human methionine aminopeptidase-2. Among the fumagillin analo gues, cinnamic acid eater derivative CKD-731 showed 1000-fold more potent p roliferation inhibitory activity on endothelial cell than TNP-470. (C) 1999 Elsevier Science Ltd. All rights reserved.