The design and synthesis of bis-[4 '-Azido-2,2 ': 6 ',2 ''-terpyridine platinum(II)] complexes with rigid and extended linkers for studying the topology of DNA by photoaffinity labeling

Authors
Lowe, G Droz, AS Park, JJ Weaver, GW
Citation
G. Lowe et al., The design and synthesis of bis-[4 '-Azido-2,2 ': 6 ',2 ''-terpyridine platinum(II)] complexes with rigid and extended linkers for studying the topology of DNA by photoaffinity labeling, BIOORG CHEM, 27(6), 1999, pp. 477-486
Citations number
6
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
BIOORGANIC CHEMISTRY
ISSN journal
00452068 → ACNP
Volume
27
Issue
6
Year of publication
1999
Pages
477 - 486
Database
ISI
SICI code
0045-2068(199912)27:6<477:TDASOB>2.0.ZU;2-6
Abstract
A family of bis-[4'-Azido-2,2':6',2 "-terpyridine platinum(II)] complexes w ith linear Linkers of varying length have been synthesized. They have been designed to bis-intercalate into two DNA duplexes in close proximity, the a zido groups allowing the sites of intercalation to be photoaffinity labeled . The linker to Pt(II) bonds are susceptible to cleavage by thiols and cyan ide ion, which is a requirement for the intended method of analysis by 2D g el electrophoresis. (C) 1999 Academic Press.