Daclizumab, a humanized anti-interleukin-2 receptor alpha chain antibody, for treatment of acute graft-versus-host disease

Citation
D. Przepiorka et al., Daclizumab, a humanized anti-interleukin-2 receptor alpha chain antibody, for treatment of acute graft-versus-host disease, BLOOD, 95(1), 2000, pp. 83-89
Citations number
53
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BLOOD
ISSN journal
00064971 → ACNP
Volume
95
Issue
1
Year of publication
2000
Pages
83 - 89
Database
ISI
SICI code
0006-4971(20000101)95:1<83:DAHARA>2.0.ZU;2-T
Abstract
Daclizumab, a humanized monoclonal IgG1 directed against the a chain of the interleukin-2 receptor (IL-2R), is a competitive inhibitor of IL-2 on acti vated lymphocytes, To test the hypothesis that specific inhibition of activ ated lymphocytes in patients with ongoing acute graft-versus-host disease ( GVHD) might ameliorate the process, we treated 43 patients with advanced or steroid-refractory GVHD with daclizumab. The first cohort of 24 patients w as treated with daclizumab 1 mg/kg on days 1, 8, 15, 22, and 29, On day 43, the complete response (CR) rate was 29% (95% confidence interval [CI], 13% -51%), Survival on day 120 was 29% (95% CI, 13%-51%), A second cohort of 19 patients was treated with daclizumab 1 mg/kg on days 1, 4, 8, 15, and 22, For these patients, the CR rate on day 43 was 47% (95% CI, 24%-71%), and su rvival on day 120 was 53% (95% CI, 29%-76%), There were no infusion-related reactions and no serious side effects related to daclizumab, Following tre atment, there was a reduction in serum concentrations of soluble IL-2R and peripheral blood CD3(+)25(+) lymphocytes, but these changes were not predic tive of response. Daclizumab has substantial activity for the treatment of acute GVHD, and the second regimen evaluated is recommended for a controlle d study. (C) 2000 by The American Society of Hematology.