Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.3.24.15) in the rat brain

Authors
Massarelli, EE Casatti, CA Kato, A Camargo, ACM Bauer, JA Glucksman, MJ Roberts, JL Hirose, S Ferro, ES
Citation
Ee. Massarelli et al., Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.3.24.15) in the rat brain, BRAIN RES, 851(1-2), 1999, pp. 261-265
Citations number
15
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
851
Issue
1-2
Year of publication
1999
Pages
261 - 265
Database
ISI
SICI code
0006-8993(199912)851:1-2<261:DSDON(>2.0.ZU;2-4
Abstract
Immunohistochemistry was used to analyze the rat brain distribution of thim et oligopeptidase and neurolysin. Both enzymes appear ubiquitously distribu ted within the entire rat brain. However, neuronal perikarya and processes stained for neurolysin, while intense nuclear labeling was only observed fo r thimet oligopeptidase. These data suggest that neurolysin and thimet olig opeptidase, endopeptidases sharing several functional and structural simila rities, are present in distinctive intracellular compartments in neuronal c ells. (C) 1999 Elsevier Science B.V. All rights reserved.