Amitriptyline increases GABA-stimulated Cl-36(-) influx by recombinant (alpha 1 gamma 2) GABA(A) receptors

Authors
Malatynska, E Miller, C Schindler, N Cecil, A Knapp, A Crites, G Rogers, H
Citation
E. Malatynska et al., Amitriptyline increases GABA-stimulated Cl-36(-) influx by recombinant (alpha 1 gamma 2) GABA(A) receptors, BRAIN RES, 851(1-2), 1999, pp. 277-280
Citations number
13
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
851
Issue
1-2
Year of publication
1999
Pages
277 - 280
Database
ISI
SICI code
0006-8993(199912)851:1-2<277:AIGCIB>2.0.ZU;2-U
Abstract
WSS-1 cells expressing (alpha 1 gamma 2)GABA(A) receptors show an augmented Cl-36(-) response to GABA in the presence of amitriptyline that is increas ed by flumazenil, unlike augmentation by diazepam which is blocked by fluma zenil. This amitriptyline effect is opposite to the inhibition of GABA-stim ulated Cl-36 influx manifested in membrane vesicles prepared from drug-naiv e rats or submissive rats (a model of depression) but is similar to that se en in tissue from amitriptyline-treated rats or dominant rats. The results suggest a novel mechanism of antidepressant drug action having a delayed on set. (C) 1999 Published by Elsevier Science B.V. All rights reserved.