Pj. Siddall et al., C-fos expression in the spinal cord of rats exhibiting allodynia followingcontusive spinal cord injury, BRAIN RES, 851(1-2), 1999, pp. 281-286
Contusive spinal cord injury (SCI) may result in central neuropathic pain m
arked by allodynia-like features in the dermatomes close to the level of in
jury. The aim of this study was to compare the laminar distribution of acti
vated neurons (as determined by c-Sos immediate early gene expression) in t
he spinal cord immediately above the level of a SCI in rats with or without
allodynia-like features. Non-noxious mechanical stimulation was applied to
half the animals in the dermatomes corresponding to the level of injury pr
ior to perfusion. Stimulation resulted in a significant increase in c-fos l
abelling in all laminae of the spinal dorsal horn in the segment immediatel
y above the level of injury only in allodynic animals. Animals that had all
odynia also demonstrated a significant increase in the level of c-fos label
ling in lamina III, IV and V of the dorsal horn without stimulation. Thus,
allodynia following SCI is associated with significant increases in basal a
nd evoked c-fos expression ("neuronal activity") in response to non-noxious
mechanical stimulation. The data also suggest that allodynia-like behaviou
r following SCI cannot be accounted for solely by changes occurring at a sp
inal level. (C) 1999 Elsevier Science B.V. All rights reserved.