Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo

Authors
Abe, K Sugiura, M Yamaguchi, S Shoyama, Y Saito, H
Citation
K. Abe et al., Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo, BRAIN RES, 851(1-2), 1999, pp. 287-289
Citations number
15
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
851
Issue
1-2
Year of publication
1999
Pages
287 - 289
Database
ISI
SICI code
0006-8993(199912)851:1-2<287:SEPAIO>2.0.ZU;2-G
Abstract
We have previously found that alcohol extract of Crocus sativus L. (CSE), c ommonly known as saffron, prevents ethanol-induced inhibition of hippocampa l long-term potentiation (LTP). In the present study, CSE (250 mg/kg, p.o.) was also effective in pl eventing acetaldehyde-induced inhibition of LTP i n the dentate gyrus of anesthetized rats. These results suggest that CSE ca n prevent aversive effects induced by ethanol and its metabolite acetaldehy de. (C) 1999 Elsevier Science B.V. All rights reserved.