In vitro activity of moxifloxacin compared to other fluoroquinolones against different erythromycin-resistant phenotypes of group A beta-hemolytic Streptococcus

The aim of the present study was to evaluate the in vitro activity of moxif loxacin (BAY 12-8039) compared to ciprofloxacin, ofloxacin and sparfloxacin against 156 group A beta-hemolytic Streptococcus strains. Sixty strains we re macrolide-, lincosamide- and streptogramin-B-susceptible; 16 strains exh ibited a constitutive resistance phenotype; 32 strains exhibited an inducib le phenotype, and 48 strains were characterized by the M-type efflux-depend ent phenotype, The minimum inhibition concentrations were determined by an agar dilution method according to NCCLS-approved guidelines. Moxifloxacin s howed an enhanced activity compared with the other fluoroquinolones against the different macrolide-resistant phenotypes. Copyright (C) 2000 S. Karger AG, Basel.