In vitro activity of moxifloxacin compared to other fluoroquinolones against different erythromycin-resistant phenotypes of group A beta-hemolytic Streptococcus

Citation
S. Esposito et al., In vitro activity of moxifloxacin compared to other fluoroquinolones against different erythromycin-resistant phenotypes of group A beta-hemolytic Streptococcus, CHEMOTHERA, 46(1), 2000, pp. 23-27
Citations number
25
Categorie Soggetti
Pharmacology,"Pharmacology & Toxicology
Journal title
CHEMOTHERAPY
ISSN journal
00093157 → ACNP
Volume
46
Issue
1
Year of publication
2000
Pages
23 - 27
Database
ISI
SICI code
0009-3157(200001/02)46:1<23:IVAOMC>2.0.ZU;2-9
Abstract
The aim of the present study was to evaluate the in vitro activity of moxif loxacin (BAY 12-8039) compared to ciprofloxacin, ofloxacin and sparfloxacin against 156 group A beta-hemolytic Streptococcus strains. Sixty strains we re macrolide-, lincosamide- and streptogramin-B-susceptible; 16 strains exh ibited a constitutive resistance phenotype; 32 strains exhibited an inducib le phenotype, and 48 strains were characterized by the M-type efflux-depend ent phenotype, The minimum inhibition concentrations were determined by an agar dilution method according to NCCLS-approved guidelines. Moxifloxacin s howed an enhanced activity compared with the other fluoroquinolones against the different macrolide-resistant phenotypes. Copyright (C) 2000 S. Karger AG, Basel.