Chemo-enzymatic synthesis of the antidepressant Duloxetine and its enantiomer

Authors
Liu, HL Hoff, BH Anthonsen, T
Citation
Hl. Liu et al., Chemo-enzymatic synthesis of the antidepressant Duloxetine and its enantiomer, CHIRALITY, 12(1), 2000, pp. 26-29
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
CHIRALITY
ISSN journal
08990042 → ACNP
Volume
12
Issue
1
Year of publication
2000
Pages
26 - 29
Database
ISI
SICI code
0899-0042(2000)12:1<26:CSOTAD>2.0.ZU;2-L
Abstract
Sodium borohydride reduction of 3-chloro-1-(2-thienyl)-1-propanone gave the corresponding racemic alcohol which was kinetically resolved with lipase B from Candida antarctica as catalyst to yield the chiral building blocks (S )-3-chloro-l-(2-thienyl)-1-propanol and the corresponding (R)-butanoate. Th e enantiopure chiral building blocks were converted into Duloxetine and its enantiomer. 2000. (C) 2000 Wiley-Liss, Inc.