Study of solubility of steroids in hydrofluoroalkane propellants

Authors
Williams, RO Rogers, TL Liu, J
Citation
Ro. Williams et al., Study of solubility of steroids in hydrofluoroalkane propellants, DRUG DEV IN, 25(12), 1999, pp. 1227-1234
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
ISSN journal
03639045 → ACNP
Volume
25
Issue
12
Year of publication
1999
Pages
1227 - 1234
Database
ISI
SICI code
0363-9045(1999)25:12<1227:SOSOSI>2.0.ZU;2-K
Abstract
The solubility of prednisone, hydrocortisone 21-acetate, hydrocortisone, de xamethasone, betamethasone 17-valerate, and danazol in hydrofluoroalkane (H FA) 134a and HFA 227 was determined at 5 degrees C and 25 degrees C. It was found that the solubility of steroid in HFA propellants was related to the melting point and the lipophilicity of the steroid. The solubility of the steroids in the binary system of HFA propellants and ethanol also was inves tigated in the study. Ethanol significantly increased the solubility of the steroids in HFA propellant. The magnitude of increase was related to the s olubility of the corresponding steroid in ethanol alone.