Development, formulation, and effectiveness testing of a silicone-based barrier-type hand cream

Citation
I. Baquerizo et al., Development, formulation, and effectiveness testing of a silicone-based barrier-type hand cream, DRUG DEV IN, 25(12), 1999, pp. 1259-1265
Citations number
12
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
ISSN journal
03639045 → ACNP
Volume
25
Issue
12
Year of publication
1999
Pages
1259 - 1265
Database
ISI
SICI code
0363-9045(1999)25:12<1259:DFAETO>2.0.ZU;2-6
Abstract
We report the development, design, and results of effectiveness and accepta bility testing of a hydrating, nutritive, barrier-type hand cream designed for severely damaged skin (including skin damaged by dermatological problem s). We tested different silicone derivatives and a water-in-oil (W/O) silic one emulsifier to produce organoleptic qualities that would increase consum er acceptance of this type of W/O emulsion. Pharmacotechnical and effective ness tests were done to check the stability and preservation of the formula s, their usefulness in improving dry skin, and acceptance by users. The res ults of pharmacotechnical testing were optimal. Although no active principl e aimed specifically at dermatological problems was present in the final fo rmulas, users reported notable subjective improvements in cracking and scal ing.