I. Baquerizo et al., Development, formulation, and effectiveness testing of a silicone-based barrier-type hand cream, DRUG DEV IN, 25(12), 1999, pp. 1259-1265
We report the development, design, and results of effectiveness and accepta
bility testing of a hydrating, nutritive, barrier-type hand cream designed
for severely damaged skin (including skin damaged by dermatological problem
s). We tested different silicone derivatives and a water-in-oil (W/O) silic
one emulsifier to produce organoleptic qualities that would increase consum
er acceptance of this type of W/O emulsion. Pharmacotechnical and effective
ness tests were done to check the stability and preservation of the formula
s, their usefulness in improving dry skin, and acceptance by users. The res
ults of pharmacotechnical testing were optimal. Although no active principl
e aimed specifically at dermatological problems was present in the final fo
rmulas, users reported notable subjective improvements in cracking and scal
ing.