Microphase separated structure and protein adsorption of polyurethanes with butadiene soft segment

Citation
Sl. Huang et al., Microphase separated structure and protein adsorption of polyurethanes with butadiene soft segment, EUR POLYM J, 36(2), 2000, pp. 285-294
Citations number
39
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN POLYMER JOURNAL
ISSN journal
00143057 → ACNP
Volume
36
Issue
2
Year of publication
2000
Pages
285 - 294
Database
ISI
SICI code
0014-3057(200002)36:2<285:MSSAPA>2.0.ZU;2-5
Abstract
Membranes of hydroxyl-terminated polybutadiene-based polyurethanes (PUs) we re prepared with different types of diisocyanates, hard segment contents an d thickness. Three effects on the molar adsorption ratio of fibrinogen to a lbumin (F/A molar ratio) of polymer surface were under investigation: the d eviation of surface from overall composition, the aggregation of hard segme nts (i.e. phase separation) and membrane thickness. The former two effects were contributed by different membrane thickness. Surface composition was q uantified by the absorbance ratio of carbonyl group to butadiene group (C=O /C=C ratio) on FTIR-ATR spectra. While phase separation is expressed by hyd rogen bonding index, which is the relative absorbance of the hydrogen bonde d carbonyl peak to that of free hydrogen bonded carbonyl peak. We found tha t a suitable phase separation or surface composition on these PU polymer su rface possess the lowest F/A molar ratio. (C) 1999 Elsevier Science Ltd. Al l rights reserved.