A randomized prospective study comparing pregnancy rates after clomiphene citrate and human menopausal gonadotropin before intrauterine insemination

Objective: To determine whether hMG offers an advantage over clomiphene cit rate (CC) in achieving pregnancy after IUI with husband's sperm. Design: Randomized prospective trial. Setting: Infertility patients in a un iversity reaching hospital. Patient(s): Fifty-eight women under 39 years old undergoing ovulation induc tion before IUI. Intervention(s): The women were assigned randomly to one of two treatment g roups. Patients in group I (CCHH) received CC for the first two cycles and hMG for the last two cycles. Patients in group Il (HHCC) received hMG for t he first two cycles and CC for the last two cycles. Main Outcome Measure(s): Cycle fecundity rates for the two treatment modali ties were compared statistically with use of life-table analysis. Result(s): Of the 174 cycles studied, overall cycle fecundity rate was 11.1 1 (9 of 81 cycles) in the CCHH group and 10.75 (10 of 93 cycles) in the NNC C group. The difference was not statistically significant, The cycle fecund ity rate was 14.44% (13 of 90 cycles) for cycles with CC and 7.14% (6 of 84 ) with hMG. The difference was not statistically significant. Conclusion(s): These data suggest that CC is an effective alternative to hM G in the population examined. (Fertil Steril(R) 2000;73:90-3. (C) 1999 by A merican Society for Reproductive Medicine.)