The stability of 15 Heterocyclic Amine (HA) standards was kinetically studi
ed during heating at 100, 150 and 200 degrees C for varied lengths of time.
Parameters used to evaluate the stability of each HA standard include the
degradation rate constant (h(-1)), the activation energy (kJ/mol) and the A
value. Results showed that the HA loss increased both with increasing temp
erature and heating time, and the degradation rate of each HA during heatin
g fits a first-order model. 2-Amino-3-dimethylimidazo[4,5-f]quinoxaline (IQ
x) was found to possess the highest stability during heating, followed by 2
-aminodipyrido[1,2-a:3',2'-d]imidazole (Glu-p-2), 9H-pyrido[4,3-b]indole (N
orharman), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4,8-trim
ethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx), 3-amino-1-methyl-5H-pyrido[4,
3-b]indole (Trp-p-2), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
, 2-amino-3,7,8-trimethylimidazo [4,5-f]quinoxaline (7,8-DiMeIQx), 1-methyl
-9H-pyrido-[4,3-b]indole (Harman), 2-amino-6-methyldipyrido-[1,2-a:3',2'-d]
imidazole (Glu-p-l), 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-p-l),
2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), 2-amino-9H-pyrido[2,3-
b]indole(A alpha C), 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C),
and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). (C) 1999 Elsev
ier Science Ltd. All rights reserved.