Stepwise solid-phase synthesis of peptide-oligonucleotide conjugates on new solid supports

Authors
Antopolsky, M Azhayev, A
Citation
M. Antopolsky et A. Azhayev, Stepwise solid-phase synthesis of peptide-oligonucleotide conjugates on new solid supports, HELV CHIM A, 82(12), 1999, pp. 2130-2140
Citations number
19
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
HELVETICA CHIMICA ACTA
ISSN journal
0018019X → ACNP
Volume
82
Issue
12
Year of publication
1999
Pages
2130 - 2140
Database
ISI
SICI code
0018-019X(1999)82:12<2130:SSSOPC>2.0.ZU;2-Z
Abstract
Several peptide-oligonucleotide and peptide-(oligonucleotide phosphorothioa te) conjugates were synthesized on new solid supports. These supports are d esigned to link the 3'-terminus of an oligonucleotide to the C-end of a pep tide via a phosphodiester or phosphorothioate bond in the process of stepwi se solid-phase assembly.